Markers of cellular senescence.
Markers of cellular senescence.
复制标题
DOI：
10.1007/978-1-62703-239-1_4
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Carnero, Amancio
中科院分区：
文献类型：
--
作者：
Carnero, Amancio
细胞衰老是一种肿瘤抑制机制，进化为限制体细胞的复制。衰老是由自然复制边界或胁迫诱导的信号造成的，例如致癌转化。肿瘤细胞可以通过基因操作和表观遗传因素，包括抗癌药物、辐射和分化剂，被迫经历衰老。衰老细胞在体外和体内都表现出不同的表型和分子特征。这些生物标志物可能是衰老诱导的原因或结果，但也可能是这些非复制细胞生理变化的副产品。
Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer drugs, radiation, and differentiating agents. Senescent cells show distinct phenotypic and molecular characteristics, both in vitro or in vivo. These biomarkers might either cause or result from senescence induction, but could also be the byproducts of physiological changes in these non-replicating cells.