Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets.
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets.
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骨桥蛋白 (Opn) 对于 1 型辅助 T (TH1) 免疫和自身免疫非常重要。然而，这种细胞因子在 TH2 介导的过敏性疾病中的作用及其对初次与二次抗原相遇的影响仍不清楚。在这里，我们证明 OPN 在哮喘个体的肺部表达，并且 Opn-s（Opn 的分泌形式）对小鼠 TH2 效应器反应和随后的过敏性气道疾病发挥相反的作用：在初次全身致敏时促炎，在继发性肺部抗原攻击时抗炎。 Opn-s 的这些作用主要是通过调节初次致敏期间抑制 TH2 的浆细胞样树突状细胞 (DC) 和二次抗原攻击期间促进 TH2 的常规 DC 来介导的。在肺部二次抗原攻击期间，重组 Opn 的治疗性给药可降低已建立的 TH2 反应并保护小鼠免受过敏性疾病。这些对 TH2 过敏反应的影响表明 Opn-s 是一个重要的治疗靶点，并为其在免疫中的作用提供了新的见解。
Osteopontin (Opn) is important for T helper type 1 (TH1) immunity and autoimmunity. However, the role of this cytokine in TH2-mediated allergic disease as well as its effects on primary versus secondary antigenic encounters remain unclear. Here we demonstrate that OPN is expressed in the lungs of asthmatic individuals and that Opn-s, the secreted form of Opn, exerts opposing effects on mouse TH2 effector responses and subsequent allergic airway disease: pro-inflammatory at primary systemic sensitization, and anti-inflammatory during secondary pulmonary antigenic challenge. These effects of Opn-s are mainly mediated by the regulation of TH2-suppressing plasmacytoid dendritic cells (DCs) during primary sensitization and TH2-promoting conventional DCs during secondary antigenic challenge. Therapeutic administration of recombinant Opn during pulmonary secondary antigenic challenge decreased established TH2 responses and protected mice from allergic disease. These effects on TH2 allergic responses suggest that Opn-s is an important therapeutic target and provide new insight into its role in immunity.
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影响因子：
4.4
作者：
McMillan, SJ;Xanthou, G;Lloyd, CM
通讯作者：
Lloyd, CM
影响因子：
15.9
作者：
Köhl, J;Baelder, R;Wills-Karp, M
通讯作者：
Wills-Karp, M
DOI：
10.1084/jem.20050631
发表时间：
2005-12-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hessel EM;Chu M;Lizcano JO;Chang B;Herman N;Kell SA;Wills-Karp M;Coffman RL
通讯作者：
Coffman RL
影响因子：
4.4
作者：
Asselin-Paturel, C;Brizard, G;Trinchieri, G
通讯作者：
Trinchieri, G
DOI：
10.1084/jem.20040035
发表时间：
2004-07-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
de Heer HJ;Hammad H;Soullié T;Hijdra D;Vos N;Willart MA;Hoogsteden HC;Lambrecht BN
通讯作者：
Lambrecht BN