Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins.
Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins.
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DOI：
10.1016/j.semcdb.2017.11.026
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发表时间：
2018-09
影响因子：
7.3
通讯作者：
Fernández-Hernando C
中科院分区：
文献类型：
--
作者：
Singh AK;Aryal B;Zhang X;Fan Y;Price NL;Suárez Y;Fernández-Hernando C
脂蛋白代谢的改变增加了心脏代谢紊乱的风险，包括2型糖尿病和动脉粥样硬化，这是西方社会的主要死亡原因。虽然脂质代谢的转录调控已被很好地表征，但最近的研究揭示了microRNA（miRNAs）、长非编码RNA（lncRNA）和RNA结合蛋白（RBP）在转录后水平调节脂质相关基因表达的重要性。来自几个小组的工作已经鉴定了许多miRNA，包括miR-33，miR-122和miR-148 a，它们在控制胆固醇稳态和脂蛋白代谢中起着重要作用。重要的是，miRNA表达失调与血脂异常有关，这表明操纵这些miRNA的表达可能是改善心血管疾病（CVD）的有用治疗方法。lncRNA在调节脂质代谢中的作用最近已经出现，并且几个组已经证明了它们对脂蛋白代谢的调节。然而，由于lncRNA的高丰度和物种之间的遗传保守性差，将需要大量的工作来阐明lncRNA在控制脂蛋白代谢中的具体作用。在这篇综述文章中，我们总结了该领域的最新研究结果，并强调了lncRNA和RBP在调节脂质代谢中的具体贡献。
Alterations in lipoprotein metabolism enhance the risk of cardiometabolic disorders including type-2 diabetes and atherosclerosis, the leading cause of death in Western societies. While the transcriptional regulation of lipid metabolism has been well characterized, recent studies have uncovered the importance of microRNAs (miRNAs), long-non-coding RNAs (lncRNAs) and RNA binding proteins (RBP) in regulating the expression of lipid-related genes at the posttranscriptional level. Work from several groups has identified a number of miRNAs, including miR-33, miR-122 and miR-148a, that play a prominent role in controlling cholesterol homeostasis and lipoprotein metabolism. Importantly, dysregulation of miRNA expression has been associated with dyslipidemia, suggesting that manipulating the expression of these miRNAs could be a useful therapeutic approach to ameliorate cardiovascular disease (CVD). The role of lncRNAs in regulating lipid metabolism has recently emerged and several groups have demonstrated their regulation of lipoprotein metabolism. However, given the high abundance of lncRNAs and the poor-genetic conservation between species, much work will be needed to elucidate the specific role of lncRNAs in controlling lipoprotein metabolism. In this review article, we summarize recent findings in the field and highlight the specific contribution of lncRNAs and RBPs in regulating lipid metabolism.
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影响因子：
20.1
作者：
Allen RM;Marquart TJ;Jesse JJ;Baldán A
通讯作者：
Baldán A
影响因子：
4.8
作者：
Gerin, Isabelle;Clerbaux, Laure-Alix;Bommer, Guido T.
通讯作者：
Bommer, Guido T.
影响因子：
5.3
作者：
Goedeke, Leigh;Vales-Lara, Frances M.;Fernandez-Hernando, Carlos
通讯作者：
Fernandez-Hernando, Carlos
影响因子：
30.8
作者：
Bodzioch, M;Orsó, E;Schmitz, G
通讯作者：
Schmitz, G
影响因子：
4
作者：
Aranda, Juan F.;Canfran-Duque, Alberto;Fernandez-Hernando, Carlos
通讯作者：
Fernandez-Hernando, Carlos