Choroidal neovascularization in pathologic myopia: Three-year results after photodynamic therapy
Choroidal neovascularization in pathologic myopia: Three-year results after photodynamic therapy
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DOI：
10.1016/j.ajo.2005.03.050
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发表时间：
2005-09-01
影响因子：
4.2
通讯作者：
Goll, A
中科院分区：
文献类型：
--
作者：
Krebs, I;Binder, S;Goll, A
目得：检查是否令人鼓舞的功能结果一年后，光动力疗法（PDT）可以维持长达3 years.DESIGN：前瞻性干预cases.METHODS：高度近视眼已与PDT治疗的中心凹下脉络膜新生血管，并已观察到至少36个月。进行远视力（糖尿病视网膜病变早期治疗表）、阅读视力（Jaeger表）、10度静态阈值视野检查、荧光素血管造影和光学相干断层扫描。结果：18例（20只眼）患者中，女性15例，男性3例，均为正常人。平均年龄为64岁（范围：36 - 85岁）。基线时的平均远视力为43个字母，12个月和36个月后为53个字母。平均阅读敏锐度从平均J10.8变为12个月后的平均J8.1，3年后的平均J9.85。平均缺陷从基线时的平均13.5 dB降至12个月后的平均12.5 dB和36个月后的平均11.2 dB。视网膜最大厚度从基线时的平均360 μ m下降到1年后的平均259 μ m和36个月后的平均238 μ m.CONCLUSION：远视力和中心视野在12个月检查后至36个月检查时显示稳定。阅读敏锐度在12个月和36个月检查之间增加，这可能与视网膜萎缩的增加有关。
PURPOSE: To examine whether the encouraging functional results one year after photodynamic therapy (PDT) can be maintained up to three years.DESIGN: Prospective interventional case series.METHODS: Highly myopic eyes that had been treated with PDT for subfoveal choroidal neovascularization and had been observed at least 36 months were included. Distance acuity (Early Treatment of Diabetic Retinopathy charts), reading acuity (Jaeger charts), 10,degree static threshold perimetry, fluorescein angiography, and optical coherence tomography were performed. The main outcome measures were the differences of the values among the baseline and the month 12 and the month 36 examinations.RESULTS: Twenty eyes of 18 patients were included: 15 patients were female, and 3 patients were male. The average age was 64 years (range, 36 to 85 years). The mean distance acuity was 43 letters at baseline and 53 letters after 12 months and after 36 months. The mean reading acuity changed from mean J10.8 to mean J8.1 after 12 months and to mean J9.85 after 3 years. The mean defect decreased from mean 13.5 dB at baseline to mean 12.5 dB after 12 months and mean 11.2 dB after 36 months. The maximum retinal thickness decreased from mean 360 mu m at baseline to mean 259 mu m after one year and mean 238 mu m after 36 months.CONCLUSION: Distance acuity and central visual field showed stabilization after the month 12 examination up to the month 36 examination. The reading acuity de, creased between the month 12 and the month 36 examinations, which might be related to an increase of retinal atrophy.