Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma.
Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma.
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应用倾向评分分析比较放射性消融、微波消融和不可逆电穿孔治疗早期肝细胞癌。
作者：
这项单中心回顾性研究旨在使用倾向评分匹配分析来比较射频消融（RFA）、微波消融（MWA）和不可逆电穿孔（IRE）治疗早期肝细胞癌（HCC）的治疗和安全性结果，以减少选择偏倚。 IRE 组和 RFA 组之间的 2 年局部肿瘤进展 (LTP) 率存在显着差异（IRE，0.0% vs. RFA，45.0%；p = 0.005）。 IRE 和 MWA 组之间（IRE，0.0% vs. MWA，25.0%；p = 0.103）以及 RFA 和 MWA 组之间（RFA，18.2% vs. MWA，20.6%；p = 0.586），2 年 LTP 率没有显着差异。 IRE 作为小型血管周围 HCC 的一线治疗选择，比 RFA 提供更好的局部肿瘤控制。背景：尽管热消融（例如射频消融（RFA）和微波消融（MWA））和非热消融（例如不可逆电穿孔（IRE））多种多样，但用于肝细胞癌（HCC）治疗的多种消融方式的交叉比较仍然很少。因此，我们研究了不同三种消融方式治疗早期 HCC 的治疗结果。方法：总共纳入了 322 名连续患有 366 个 HCC 的患者（平均肿瘤大小±标准差：1.7±0.9 cm），这些患者接受了 RFA（n = 216，59.0%）、MWA（n = 91，28.3%）或 IRE（n = 15，4.7%）。比较了三种治疗方式中 LTP 的局部肿瘤进展 (LTP) 率。倾向评分匹配分析用于减少选择偏差。结果：发现 IRE 组和 RFA 组之间的 2 年 LTP 率存在显着差异（IRE，0.0% vs. RFA，45.0%；p = 0.005）。 IRE 和 MWA 组之间（IRE，0.0% vs. MWA，25.0%；p = 0.103）以及 RFA 和 MWA 组之间（RFA，18.2% vs. MWA，20.6%；p = 0.586），2 年 LTP 率没有显着差异。结论：IRE 作为小血管周围 HCC 的一线治疗选择，比 RFA 提供更好的局部肿瘤控制。
This single-center retrospective study aimed to compare the therapeutic and safety outcomes of radiofrequency ablation (RFA), microwave ablation (MWA), and irreversible electroporation (IRE) in the treatment of early stage hepatocellular carcinoma (HCC) using propensity score-matched analysis to reduce selection bias. A significant difference in 2-year local tumor progression (LTP) rates between the IRE and RFA groups (IRE, 0.0% vs. RFA, 45.0%; p = 0.005) was found. There was no significant difference in 2-year LTP rates between the IRE and MWA groups (IRE, 0.0% vs. MWA, 25.0%; p = 0.103) as well as between the RFA and MWA groups (RFA, 18.2% vs. MWA, 20.6%; p = 0.586). IRE provides better local tumor control than RFA as a first-line therapeutic option for small perivascular HCC. Background: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IRE) cross-comparisons of multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated the therapeutic outcomes of different three ablation modalities in the treatment of early stage HCC. Methods: A total of 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 ± 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA (n = 91, 28.3%), or IRE (n = 15, 4.7%) were included. Local tumor progression (LTP) rates for LTP were compared among the three modalities. Propensity score-matched analysis was used to reduce selection bias. Results: A significant difference in 2-year LTP rates between the IRE and RFA groups (IRE, 0.0% vs. RFA, 45.0%; p = 0.005) was found. There was no significant difference in 2-year LTP rates between the IRE and MWA groups (IRE, 0.0% vs. MWA, 25.0%; p = 0.103) as well as between the RFA and MWA groups (RFA, 18.2% vs. MWA, 20.6%; p = 0.586). Conclusion: IRE provides better local tumor control than RFA as a first-line therapeutic option for small perivascular HCC.
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DOI：
10.1007/s00262-020-02734-1
发表时间：
2021-04
期刊：
Cancer immunology, immunotherapy : CII
影响因子：
--
作者：
Leuchte K;Staib E;Thelen M;Gödel P;Lechner A;Zentis P;Garcia-Marquez M;Waldschmidt D;Datta RR;Wahba R;Wybranski C;Zander T;Quaas A;Drebber U;Stippel DL;Bruns C;von Bergwelt-Baildon M;Wennhold K;Schlößer HA
通讯作者：
Schlößer HA
影响因子：
1.8
作者：
Sugimoto, Katsutoshi;Moriyasu, Fuminori;Itoi, Takao
通讯作者：
Itoi, Takao
影响因子：
19.7
作者：
Sutter, Olivier;Calvo, Joyce;Seror, Olivier
通讯作者：
Seror, Olivier
DOI：
10.1016/j.jvir.2014.08.027
发表时间：
2014-11
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Ahmed M;Solbiati L;Brace CL;Breen DJ;Callstrom MR;Charboneau JW;Chen MH;Choi BI;de Baère T;Dodd GD 3rd;Dupuy DE;Gervais DA;Gianfelice D;Gillams AR;Lee FT Jr;Leen E;Lencioni R;Littrup PJ;Livraghi T;Lu DS;McGahan JP;Meloni MF;Nikolic B;Pereira PL;Liang P;Rhim H;Rose SC;Salem R;Sofocleous CT;Solomon SB;Soulen MC;Tanaka M;Vogl TJ;Wood BJ;Goldberg SN;International Working Group on Image-Guided Tumor Ablation;Interventional Oncology Sans Frontières Expert Panel;Technology Assessment Committee of the Society of Interventional Radiology;Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
通讯作者：
Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
影响因子：
3.8
作者：
Guo X;Du F;Liu Q;Guo Y;Wang Q;Huang W;Wang Z;Ding X;Wu Z
通讯作者：
Wu Z