Basal Ganglia Shapes Predict Social, Communication, and Motor Dysfunctions in Boys With Autism Spectrum Disorder
Basal Ganglia Shapes Predict Social, Communication, and Motor Dysfunctions in Boys With Autism Spectrum Disorder
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DOI：
10.1016/j.jaac.2010.02.012
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发表时间：
2010-06-01
影响因子：
13.3
通讯作者：
Mostofsky, Stewart H.
中科院分区：
文献类型：
--
作者：
Qiu, Anqi;Adler, Marcy;Mostofsky, Stewart H.
目的：基底神经节异常被认为是导致自闭症谱系障碍（ASD）的运动、社交和交流障碍的原因。容量分析提供有限的能力来检测基底神经节结构的局部差异。我们的目的是研究基底神经节形状异常及其与ASD行为特征的关系，ASD可能涉及多个额叶皮层下回路。方法：对32例ASD患儿和45例正常发育（TD）患儿的MRI图像进行基底节区人工勾画。使用大变形神经形态测量标测（LDDMM）来评估基底神经节形状的组间差异，并检查ASD中与运动、实践和相互社交和沟通障碍的相关性。结果如下：与TD男孩相比，ASD男孩的右侧基底神经节形状发生变化;尾状核、壳核和苍白球存在表面变形，但无法进行多重比较校正。大脑行为相关性的研究结果更强大，多重比较分析显示，在ASD男孩中，右后壳核的表面向内变形预测较差的运动技能，而双侧前壳核和后壳核的表面向内变形预测较差的实践。双侧内侧尾状核头部的表面向外变形预示着更大的相互社会和交流障碍。结论：ASD男孩的运动、社交和交流障碍与基底神经节的形状异常有关。研究结果表明，平行额叶皮层下回路的异常与ASD中运动和互惠社交和沟通技能的获得受损有差异。J. Am. Acad.儿童青少年精神病学，2010;49（6）：539-551.
Objective: Basal ganglia abnormalities have been suggested as contributing to motor, social, and communicative impairments in autism spectrum disorder (ASD). Volumetric analyses offer limited ability to detect localized differences in basal ganglia structure. Our objective was to investigate basal ganglia shape abnormalities and their association with behavioral features of ASD, which may involve multiple frontal subcortical circuits. Method: Basal ganglia were manually delineated from MR images of 32 boys with ASD and 45 typically developing (TD) boys. Large deformation diffeomorphic metric mapping (LDDMM) was used to assess between-group differences in basal ganglia shape and to examine associations with motor, praxis, and reciprocal social and communicative impairments in ASD. Results: Boys with ASD showed changes in right basal ganglia shape as compared with TD boys; surface deformation was present in the caudate, putamen, and globus pallidus but did not stand up to correction for multiple comparisons. Brain-behavior correlation findings were more robust; analyses accounting for multiple comparisons revealed, in boys with ASD, surface inward deformation of the right posterior putamen predicted poorer motor skill, whereas surface inward deformation of the bilateral anterior and posterior putamen predicted poorer praxis. Surface outward deformation in the bilateral medial caudate head predicted greater reciprocal social and communicative impairment. Conclusions: Motor, social, and communicative impairments in boys with ASD are associated with shape abnormalities in the basal ganglia. The findings suggest abnormalities within parallel frontal subcortical circuits are differentially associated with impaired acquisition of motor and reciprocal social and communicative skills in ASD. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(6):539-551.