Development of antiviral drugs for the treatment of AIDS: strategies and prospects.
Development of antiviral drugs for the treatment of AIDS: strategies and prospects.
复制标题
治疗艾滋病的抗病毒药物的开发：策略和前景。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
W. Haseltine
中科院分区：
文献类型：
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作者：
W. Haseltine
这一综述清楚地表明，开发用于治疗艾滋病的抗病毒药物有许多可能性。基于对特定酶调节蛋白和病毒复制的结构要求的深刻理解的药物设计是可能的。调节这些特定过程的信息正在迅速增加，并将进一步加快临床前药物设计。随着时间的推移，这种开发抗艾滋病药物的协同努力将从根本上改变治疗其他疾病的药物设计方法。
This review makes it clear that there are numerous possibilities for the development of antiviral drugs for the treatment of AIDS. Drug design based on a profound understanding of specific enzymatic regulatory proteins and structural requirements for virus replication is possible. Information regulating these specific processes is increasing rapidly and will further speed preclinical drug design. Over time, this concerted effort to develop anti-AIDS drugs will radically alter the approach to the design of drugs for the treatment of other diseases.