Salivary gland branching morphogenesis--recent progress and future opportunities.
Salivary gland branching morphogenesis--recent progress and future opportunities.
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DOI：
10.4248/ijos10042
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发表时间：
2010-09
影响因子：
14.9
通讯作者：
Yamada KM
中科院分区：
文献类型：
--
作者：
Hsu JC;Yamada KM
唾液腺提供唾液以维持口腔健康，并且唾液腺功能的丧失大大降低生活质量。了解在胚胎发育过程中产生唾液腺的生物学机制可能会发现新的方法来再生功能或设计人工唾液腺。本文综述了唾液腺分支形态发生过程的研究进展。我们强调了令人兴奋的新进展和机会，在细胞间相互作用，机械力，生长因子和基因表达模式的研究，以提高我们对这一重要过程的理解。
Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.