Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways.
Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways.
复制标题
细胞质 RIG-I 和 STING 传感通路之间的串扰。
DOI：
10.1016/j.it.2016.12.004
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发表时间：
2017-03
影响因子：
16.8
通讯作者：
Hiscott J
中科院分区：
文献类型：
--
作者：
Zevini A;Olagnier D;Hiscott J
通过宿主免疫传感器检测微生物病原体上的进化保守分子代表了针对感染的免疫应答的初始触发。胞质受体感知病毒和细胞内细菌基因组，以及复制过程中产生的核酸。一旦被激活，这些传感器触发多个信号级联，集中在I型干扰素和促炎细胞因子的产生上。虽然不同类别的受体负责RNA和DNA传感，但下游信号传导组分在物理上和功能上相互连接。这篇综述将强调RIG-I-MAVS RNA传感和cGAS-STING DNA传感途径之间的串扰在增强有效的抗病毒反应中的重要性。cGAS-STING操作作为癌症免疫治疗的一个组成部分的潜力也将进行审查。
Detection of evolutionary conserved molecules on microbial pathogens by host immune sensors represents the initial trigger of the immune response against infection. Cytosolic receptors sense viral and intracellular bacterial genomes, as well as nucleic acids produced during replication. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Although distinct classes of receptors are responsible for the RNA and DNA sensing, the downstream signaling components are physically and functionally interconnected. This review will highlight the importance of the crosstalk between RIG-I-MAVS RNA sensing and the cGAS-STING DNA sensing pathways in potentiating efficient antiviral responses. The potential of cGAS-STING manipulation as a component of cancer immunotherapy will also be reviewed.