ULTRASTRUCTURE OF HUMAN PLACENTA AT TERM - OBSERVATIONS ON PLACENTAS FROM NEWBORN CHILDREN OF SMOKING AND NON-SMOKING MOTHERS
ULTRASTRUCTURE OF HUMAN PLACENTA AT TERM - OBSERVATIONS ON PLACENTAS FROM NEWBORN CHILDREN OF SMOKING AND NON-SMOKING MOTHERS
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DOI：
10.3109/00016347709158353
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发表时间：
1977-01-01
影响因子：
4.3
通讯作者：
ASMUSSEN, I
中科院分区：
文献类型：
--
作者：
ASMUSSEN, I
选择胎盘作为评估吸烟引起的人体血管损伤和组织损伤的可能模型。对4例吸烟者和3例非吸烟者的足月胎盘进行了透射电镜观察。在吸烟者组中发现了明显的变化。特征性表现为胎盘绒毛基底膜增宽，绒毛胶原含量增加，绒毛毛细血管和小动脉血管化减少，内膜水肿明显。由于之前在人脐动脉中报告了类似的变化，并且由于暴露于CO或灌注尼古丁也会在动物动脉中诱导这些变化，因此支持吸烟对人体血管系统和组织有害的概念。
The placenta was chosen as a possible model for evaluating the vascular injury and tissue injury provoked by tobacco smoking in the human body. Full term placentas from 4 smokers and 3 non-smokers were studied in the transmission electron microscope. Pronounced changes were found in the group of smokers. The characteristic findings were broadening of the basement membrane of the placental villus, increase in collagen content of the villus, decrease in vascularization and initimal changes in the villous capillaries and arterioles, with pronounced intimal edema. Since similar changes were previously reported from human umbilical arteries, and since these changes were also induced in animal arteries by exposure to CO or perfusion with nicotine, the concept that tobacco smoking is harmful to the human vascular system and tissues was supported.