FatiGO:: a web tool for finding significant associations of Gene Ontology terms with groups of genes
FatiGO:: a web tool for finding significant associations of Gene Ontology terms with groups of genes
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DOI：
10.1093/bioinformatics/btg455
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发表时间：
2004-03-01
期刊：
影响因子：
5.8
通讯作者：
Dopazo, J
中科院分区：
文献类型：
--
作者：
Al-Shahrour, F;Díaz-Uriarte, R;Dopazo, J
摘要：我们提出了一种简单但强大的程序，用于提取在基因组规模实验（DNA微阵列、蛋白质组学等）背景下，在基因集中显著过度表达或表达不足的基因本体论（GO）术语。所述程序已作为一个网络应用程序FatiGO实现，允许轻松和交互式查询。FatiGO考虑到了统计对比的多重检验性质，目前包括多种生物（人类、小鼠、果蝇、线虫和酵母）的GO关联以及来自欧洲生物信息学研究所的TrEMBL/Swissprot GO注释@EBI对应关系。
Summary: We present a simple but powerful procedure to extract Gene Ontology (GO) terms that are significantly over- or under-represented in sets of genes within the context of a genome-scale experiment (DNA microarray, proteomics, etc.). Said procedure has been implemented as a web application, FatiGO, allowing for easy and interactive querying. FatiGO, which takes the multiple-testing nature of statistical contrast into account, currently includes GO associations for diverse organisms (human, mouse, fly, worm and yeast) and the TrEMBL/Swissprot GOAnnotations@EBI correspondences from the European Bioinformatics Institute.