Hyperbaric oxygen therapy and preconditioning for ischemic and hemorrhagic stroke.
Hyperbaric oxygen therapy and preconditioning for ischemic and hemorrhagic stroke.
复制标题
高压氧疗法以及缺血性和出血性中风的预处理。
DOI：
10.4103/2045-9912.196907
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发表时间：
2016-10
影响因子：
2.9
通讯作者：
Xi GH
中科院分区：
文献类型：
--
作者：
Hu SL;Feng H;Xi GH
迄今为止，缺血性和出血性脑卒中的治疗方法仍然有限。缺氧是中风后脑损伤的关键。高压氧（HBO）是一种通过患者在超过101 kPa的压力下吸入100%纯氧的方法，已被证明有助于氧气输送并增加氧气供应。因此，高压氧有可能对脑卒中产生有益的影响。事实上，大量的基础和临床证据表明，高压氧治疗和预处理通过不同的机制发挥神经保护作用。然而，临床转化研究的缺乏限制了高压氧的应用。未来需要更多的转化研究和临床试验来开发有效的HBO方案。
To date, the therapeutic methods for ischemic and hemorrhagic stroke are still limited. The lack of oxygen supply is critical for brain injury following stroke. Hyperbaric oxygen (HBO), an approach through a process in which patients breathe in 100% pure oxygen at over 101 kPa, has been shown to facilitate oxygen delivery and increase oxygen supply. Hence, HBO possesses the potentials to produce beneficial effects on stroke. Actually, accumulated basic and clinical evidences have demonstrated that HBO therapy and preconditioning could induce neuroprotective functions via different mechanisms. Nevertheless, the lack of clinical translational study limits the application of HBO. More translational studies and clinical trials are needed in the future to develop effective HBO protocols.