Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).
Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).
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巨细胞病毒性视网膜炎：获得性免疫缺陷综合征（艾滋病）的一种表现。
DOI：
10.1136/bjo.67.6.372
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Mathur,U
中科院分区：
文献类型：
--
作者：
Friedman,AH;Orellana,J;Freeman,WR;Luntz,MH;Starr,MB;Tapper,ML;Spigland,I;Roterdam,H;MesaTejada,R;Braunhut,S;Mildvan,D;Mathur,U
两名患有“同性恋肠综合症”的同性恋男性经历了急性单侧视力丧失。两名患者均出现白色视网膜内病变，并融合。其中一名病例细胞介导的免疫功能低下；两名患者在长期患病后最终死亡。一名患者从玻璃体活检中培养出巨细胞病毒。尸检显示两名患者均存在播散性巨细胞病毒。广泛的视网膜坏死很明显，具有典型的核和细胞质包涵体电子显微镜显示疱疹病毒，而免疫过氧化物酶技术显示同性恋患者中细胞介导的反应改变可能是导致卡波西肉瘤和卡氏肺囊虫、单纯疱疹或巨细胞病毒的机会性感染的原因。
Two homosexual males with the "gay bowel syndrome' experienced an acute unilateral loss of vision. Both patients had white intraretinal lesions, which became confluent. One of the cases had a depressed cell-mediated immunity; both patients ultimately died after a prolonged illness. In one patient cytomegalovirus was cultured from a vitreous biopsy. Autopsy revealed disseminated cytomegalovirus in both patients. Widespread retinal necrosis was evident, with typical nuclear and cytoplasmic inclusions of cytomegalovirus. Electron microscopy showed herpes virus, while immunoperoxidase techniques showed cytomegalovirus. The altered cell-mediated response present in homosexual patients may be responsible for the clinical syndromes of Kaposi's sarcoma and opportunistic infection by Pneumocystis carinii, herpes simplex, or cytomegalovirus.