DOPAMINE-BETA-HYDROXYLASE (DBH) AND HOMOVANILLIC-ACID (HVA) IN AUTISTIC-CHILDREN
DOPAMINE-BETA-HYDROXYLASE (DBH) AND HOMOVANILLIC-ACID (HVA) IN AUTISTIC-CHILDREN
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DOI：
10.1007/bf01531575
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发表时间：
1986-03-01
影响因子：
3.9
通讯作者：
LELORD, G
中科院分区：
文献类型：
--
作者：
GARNIER, C;COMOY, E;LELORD, G
本研究测定了19名孤独症儿童和15名正常儿童的血浆DBH活性和尿HVA水平。DBH活性显着升高，在8个较低的弱智自闭症患者。在这个亚组中，发现血浆DBH和尿HVA水平之间呈负相关。这些结果支持了自闭症症状的产生可能涉及脑儿茶酚胺功能障碍的假设。
In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.