Robustness and Universality in Organelle Size Control.
Robustness and Universality in Organelle Size Control.
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DOI：
10.1103/physrevlett.130.018401
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发表时间：
2023-01
影响因子：
8.6
通讯作者：
K. P. Amiri;Asa Kalish;S. Mukherji
中科院分区：
文献类型：
--
作者：
K. P. Amiri;Asa Kalish;S. Mukherji
细胞生物物理学的一个重大挑战是理解细胞组装和维持亚细胞结构的精确性。例如，细胞器的大小必须足够灵活，以允许细胞在环境要求下生长或收缩，同时保持在稳态范围内。尽管确定的分子因素，调节细胞器的大小，我们缺乏深入了解细胞器大小控制的定量原则。在这里，我们的实验表明，细胞可以鲁棒地控制细胞器大小的平均波动。通过证明细胞器的大小服从我们理论上预测的普遍尺度关系，我们的框架表明细胞器从有限的构建块池中随机爆发生长。爆发式生长提供了一种一般的生物物理机制，通过这种机制，细胞可以保持平均可靠但可塑的细胞器大小。
One of the grand challenges in cellular biophysics is understanding the precision with which cells assemble and maintain subcellular structures. Organelle sizes, for example, must be flexible enough to allow cells to grow or shrink them as environments demand yet be maintained within homeostatic limits. Despite identification of molecular factors that regulate organelle sizes we lack insight into the quantitative principles underlying organelle size control. Here we show experimentally that cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey a universal scaling relationship we predict theoretically, our framework suggests that organelles grow in random bursts from a limiting pool of building blocks. Burstlike growth provides a general biophysical mechanism by which cells can maintain on average reliable yet plastic organelle sizes.