Cortisol effects on body mass, blood pressure, and cholesterol in the general population
Cortisol effects on body mass, blood pressure, and cholesterol in the general population
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DOI：
10.1161/01.hyp.33.6.1364
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发表时间：
1999-06-01
期刊：
影响因子：
8.3
通讯作者：
Connell, JMC
中科院分区：
文献类型：
--
作者：
Fraser, R;Ingram, MC;Connell, JMC
过量皮质醇分泌对血压和脂肪沉积的影响已有大量文献记载，但这种糖皮质激素在控制正常人这些过程中的重要性尚不清楚。我们研究了439名（238名男性）来自苏格兰格拉斯哥北部的正常人的皮质醇排泄率（四氢皮质醇[THF]+allo-THF+四氢可的松[THE]）与一系列重要的心血管危险因素之间的关系。性别差异明显：女性受试者体重较轻，血压和皮质醇水平较低，而HDL胆固醇较高。皮质醇代谢模式也不同; 11 β-羟基类固醇脱氢酶活性指数（THF+allo-THF/THF）较低，5 α-还原酶活性指数（allo-THF/THF）较高。血压（阳性）、胆固醇（阳性）和HDL胆固醇（女性阴性，男性阳性）与年龄有很强的相关性。皮质醇排泄率与血压无关，但与体型参数（体重指数和腰围和臀围测量值[阳性]）和HDL胆固醇（阴性）密切相关。多元回归分析显示，男性和女性的皮质醇排泄率与高密度脂蛋白胆固醇以及男性的体重指数仍有显著相关性。这些结果表明，糖皮质激素调节心血管风险的关键组成部分。
The effects of excess cortisol secretion on blood pressure and fat deposition are well documented, but the importance of this glucocorticoid in controlling these processes in normal individuals is less clear. We studied the relationship between cortisol excretion rate (tetrahydrocortisol [THF]+allo-THF+tetrahydrocortisone [THE]) and a range of important cardiovascular risk factors in 439 normal subjects (238 male) sampled from the North of Glasgow (Scotland) population. There were marked gender differences: female subjects were lighter and had lower blood pressures and cortisol levels, whereas HDL cholesterol was higher. The pattern of cortisol metabolism was also different; the index of 11 beta-hydroxysteroid dehydrogenase activity (THF+allo-THF/THF) was lower and that of 5 alpha-reductase (allo-THF/THF) was higher. There was a strong correlation of blood pressure (positive), cholesterol (positive), and HDL cholesterol (negative in women, positive in men) with age. Cortisol excretion rate did not correlate with blood pressure but correlated strongly with parameters of body habitus (body mass index and waist and hip measurements [positive]) and HDL cholesterol (negative). With multiple regression analysis, there remained a significant association of cortisol excretion rate with HDL cholesterol in men and women and with body mass index in men. These results suggest that glucocorticoids regulate key components of cardiovascular risk.