Molecular Cloning of the Swine Interleukin-23 Subunit p19 and of its Receptor Components Interleukin-23Rα and -12Rβ1
Molecular Cloning of the Swine Interleukin-23 Subunit p19 and of its Receptor Components Interleukin-23Rα and -12Rβ1
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DOI：
10.1292/jvms.11-0255
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发表时间：
2012-03-01
影响因子：
1.2
通讯作者：
Yasue, Hiroshi
中科院分区：
文献类型：
--
作者：
Kokuho, Takehiro;Hoang Vu Dang;Yasue, Hiroshi
IL-12和IL-23分别在调节不同的辅助性T细胞亚群，即Th1和Th17中起核心作用。尽管IL-12和IL-23已经在人类和啮齿动物系统中得到了很好的研究，但对它们在其他动物中的意义却知之甚少，包括家畜哺乳动物，如牛和猪。在本研究中，我们对猪IL-23的一个小分子组分进行了分子克隆和基因特征分析。此外，我们还对其受体(R)亚单位IL-23Rα和IL-12Rβ1的编码基因进行了染色体定位。这些结果提供了猪IL-23/IL-23R和IL-12/IL-12R系统的遗传信息，有助于更好地了解参与猪免疫的IL-12/IL-23系统。
Interleukin (IL)-12 and IL-23 play central roles in the regulation of distinct helper T-cell subsets, i.e. Th1 and Th17, respectively. Although IL-12 and IL-23 have been well studied in human and rodent systems, little is known about their significance in other animals, including livestock mammals such as cattle and pigs. In this study, we performed molecular cloning and genetic characterization of a small component of swine IL-23. IL-23p19; in addition, we identified and performed chromosomal assignment of the genes encoding its receptor (R) subunits IL-23R alpha and IL-12R beta 1. These results provide genetic information about both swine IL-23/IL-23R and IL-12/IL-12R systems, which allows for better understanding of IL-12/IL-23 systems involved in pig immunity.