Eosinophilia VI, spontaneous synthesis of chemokinetic, chemotactic, complement receptor‐inducing activities for eosinophils by bronchial T lymphocytes of asthmatic‐bronchitic patients
Eosinophilia VI, spontaneous synthesis of chemokinetic, chemotactic, complement receptor‐inducing activities for eosinophils by bronchial T lymphocytes of asthmatic‐bronchitic patients
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嗜酸性粒细胞增多 VI，哮喘-支气管炎患者的支气管 T 淋巴细胞自发合成嗜酸性粒细胞趋化、趋化、补体受体诱导活性
DOI：
10.1111/j.1365-2222.1982.tb01646.x
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发表时间：
1982
影响因子：
6.1
通讯作者：
E. Luckhurst
中科院分区：
文献类型：
--
作者：
W. Parish;E. Luckhurst
从5例外源性哮喘和慢性轻度支气管炎患者的支气管粘液中分离出T淋巴细胞，这些患者的支气管粘液中有大量的嗜酸性粒细胞，但无明显的血液嗜酸性粒细胞。未经抗原或有丝分裂原处理的支气管淋巴细胞自发地向无血清合成介质中释放一种或多种分子量在30,000-60,000道尔顿之间的物质。这些物质在正常人的嗜酸性粒细胞上测试时，刺激随机运动(趋化)，吸引它们(趋化)，增强它们对激活的补体的趋化反应，并增加C4和C3b受体的表达。中性粒细胞的化学运动和趋化活性较弱。用嘌呤霉素抑制合成的支气管淋巴细胞培养中未发现嗜酸性粒细胞刺激活性。血淋巴细胞不会自发合成这种物质(S)。
T lymphocytes were separated from the bronchial mucus of five patients with extrinsic asthma and chronic mild bronchitis and who had numerous eosinophils in the bronchial mucus but no significant blood eosinophilia. The bronchial lymphocytes spontaneously, that is without treatment with antigens or mitogens, released into serum‐free synthetic medium one or more substances in the molecular weight range of 30 000 to 60 000 daltons. These substances when tested on eosinophils of normal persons stimulated random movement (chemokinesis), attracted them (chemotaxis), enhanced their chemotactic response to activated complement, and increased the expression of C4 and C3b receptors. Chemokinetic and chemotactic activity for neutropils was weak. No eosinophil‐stimulating activity was found in cultures of bronchial lymphocytes treated with puromycin to inhibit synthesis. The blood lymphocytes did not spontaneously synthesize the substance(s).