Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus
Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus
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DOI：
10.1128/jcm.43.10.5285-5287.2005
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发表时间：
2005-10-01
影响因子：
9.4
通讯作者：
Weinstein, RA
中科院分区：
文献类型：
--
作者：
Hayden, MK;Rezai, K;Weinstein, RA
达托霉素是一种新型脂肽类抗生素，对金黄色葡萄球菌具有快速杀菌作用。我们报告了2例因耐甲氧西林沙门氏菌引起骨髓炎的达托霉素耐药和治疗失败。金黄色。纸片扩散药敏试验未能检测到耐药性。达托霉素在高浓度下对耐药菌株保持杀菌活性。
Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.