Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.
Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.
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DOI：
10.1002/hipo.450010206
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发表时间：
1991-04-01
期刊：
影响因子：
3.5
通讯作者：
Wible, C G
中科院分区：
文献类型：
--
作者：
Otto, T;Eichenbaum, H;Wible, C G
最近的研究揭示了3种刺激参数，它们共同构成了最适合诱导海马LTP的神经元激活的时间模式：高频脉冲，脉冲前100-200毫秒的活动，以及与正在进行的海马θ节律相一致的脉冲传递。这篇论文报道了这三个方面的模式神经活动，统称为“θ -爆发”，是大鼠在气味识别任务和空间记忆任务中学习线索的采样和分析过程中CA1锥体细胞尖峰序列的特征。相反，在与任务相关的记忆处理不太直接相关的行为事件中，θ -爆发发生的频率相对较低。这些发现表明，诱导LTP的最佳条件自然发生在行为动物身上，它们被时间锁定在对学习至关重要的行为事件上。
Recent studies have revealed 3 stimulation parameters that together comprise the temporal pattern of neuronal activation optimal for the induction of hippocampal LTP: high-frequency bursts, activity 100-200 ms prior to a burst, and burst delivery in phase with the ongoing hippocampal theta rhythm. The present paper reports that these 3 aspects of patterned neural activity, collectively referred to as "theta-bursting," are characteristic of the spike trains of CA1 pyramidal cells in rats during the sampling and analysis of learning cues in an odor discrimination task and during performances of a spatial memory task. In contrast, theta-bursting occurs relatively infrequently during behavioral events less directly related to task-relevant mnemonic processing. These findings suggest that the optimal conditions for the induction of LTP occur naturally in behaving animals, time-locked to behavioral events critical to learning.