IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
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DOI：
10.1073/pnas.0902745106
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发表时间：
2009-04-28
影响因子：
11.1
通讯作者：
Paul, William E.
中科院分区：
文献类型：
--
作者：
Ben-Sasson, Shlomo Z.;Hu-Li, Jane;Paul, William E.
IL-1引起幼稚和记忆CD 4 T细胞响应其同源抗原攻击的扩增程度显著增加。当只有特定的CD 4 T细胞可以对IL-1 β产生应答时，这种应答发生，不受一系列其他细胞因子的诱导，也不依赖于IL-6或CD-28。当WT细胞在IL-1 R1（-/-）接受者中引发时，IL-1增加了产生精氨酸的转基因CD 4 T细胞的比例，特别是产生IL-17和IL-4的细胞，显著增加了血清IgE水平和血清IgG 1水平。IL-1 β增强转移至IL-1 R1（-/-）受体的体外致敏Th 1、Th 2和Th 17细胞的抗原介导的扩增IL-1受体拮抗剂使对抗原加脂多糖（LPS）的反应减少约55%。这些结果表明，T细胞中的IL-1 β信号传导显著诱导稳健和持久的初级和次级CD 4应答。
IL-1 causes a marked increase in the degree of expansion of naive and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1 beta, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1(-/-) recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1 beta enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1(-/-) recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by approximate to 55%. These results indicate that IL-1 beta signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.