Drosophila visual transduction.
Drosophila visual transduction.
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DOI：
10.1016/j.tins.2012.03.004
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发表时间：
2012-06
影响因子：
15.9
通讯作者：
Montell C
中科院分区：
文献类型：
--
作者：
Montell C
Visual transduction in the Drosophila compound eye functions through a pathway that couples rhodopsin to phospholipase C (PLC) and the opening of Transient Receptor Potential (TRP) channels. This cascade differs from phototransduction in mammalian rods and cones, but is remarkably similar to signaling in mammalian intrinsically photosensitive retinal ganglion cells (ipRGCs). This review focuses on recent advances in the fly visual system, including the discovery of a visual cycle and insights into the machinery involved in generating a light response in photoreceptor cells. These latest findings suggest that the mechanism of light detection in flies and mammals have important parallels. Thus, a better understanding of phototransduction in the fly has the potential to contribute to our understanding of light detection in mammalian ipRGCs.
