Vascular development in endometriosis
Vascular development in endometriosis
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DOI：
10.1007/s10456-005-9005-x
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发表时间：
2005-01-01
期刊：
影响因子：
9.8
通讯作者：
Gruemmer, R.
中科院分区：
文献类型：
--
作者：
Groothuis, P. G.;Nap, A. W.;Gruemmer, R.
子宫内膜异位症是一种雌激素依赖性疾病，其定义为子宫外存在子宫内膜组织，可导致育龄妇女盆腔疼痛和生育能力低下。这种情况对患者的职业，社会和婚姻生活产生了巨大的影响。直接和间接的证据表明，血管生成是子宫内膜异位症的发展和持续所必需的。在这篇综述中，我们将讨论血管生成在异位种植和月经期子宫内膜组织存活中的作用。
Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.