The progression of benign prostatic hyperplasia: Examining the evidence and determining the risk
The progression of benign prostatic hyperplasia: Examining the evidence and determining the risk
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DOI：
10.1159/000052475
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发表时间：
2001-04-01
期刊：
影响因子：
23.4
通讯作者：
Emberton, M
中科院分区：
文献类型：
--
作者：
Anderson, JB;Roehrborn, CG;Emberton, M
背景：良性前列腺增生 (BPH) 通常与前列腺肿大、下尿路症状、尿流量减少和生活质量下降有关。此外，如果与 BPH 相关的症状不及时治疗，可能会出现严重的并发症，例如急性尿潴留。长期临床研究的证据表明，BPH 是一种进行性疾病，一些患者的进展速度比其他患者快得多。 目的：本文旨在从分子、病理和临床角度探讨 BPH 进展的自然史，重点关注支持该疾病进行性性质的关键临床证据。还讨论了我们对这种疾病和 BPH 进展的危险因素的进一步了解如何应用于改善当前的管理实践。结论：除了短期治疗外，识别高危患者的策略和针对长期管理的指南可能有助于预防 BPH 进展。版权所有 (C) 2007 S. Karger AG。巴塞尔。
Background: Benign prostatic hyperplasia (BPH) is often associated with enlargement of the prostate gland, lower urinary tract symptoms, decreased urinary flow and a reduced quality of life. Furthermore, if the symptoms associated with BPH are left untreated, serious complications, such as acute urinary retention, may ensue. Evidence is emerging from long-term clinical studies to suggest that BPH is a progressive disease, with some patients progressing much more rapidly than others.Objective: This article aims to explore the natural history of BPH progression from a molecular, pathological and clinical perspective, with emphasis on the key clinical evidence to support the progressive nature of this disease. How our increased understanding of the disease and of the risk factors for BPH progression might be applied to improve current management practices are also discussed.Conclusion: Strategies to identify patients most at risk and guidelines directed towards longterm management, in addition to short-term treatment, may be useful in helping to prevent BPH progression. Copyright (C) 2007 S. Karger AG. Basel.