Effect of Rebamipide Ophthalmic Suspension on Optical Quality in the Short Break-up Time Type of Dry Eye
Effect of Rebamipide Ophthalmic Suspension on Optical Quality in the Short Break-up Time Type of Dry Eye
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DOI：
10.1097/ico.0b013e318294f97e
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发表时间：
2013-09-01
期刊：
影响因子：
2.8
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Koh, Shizuka;Inoue, Yasushi;Nishida, Kohji
目的：目的：观察瑞巴派特眼用混悬液对泪膜破裂时间（breakuptime，BUT）较短的干眼症患者光学质量的影响。分别于治疗前、治疗后2周和4周进行角膜高阶像差（HOA）、BUT、荧光素染色和Schirmer试验。结果：治疗前，患者眨眼后10 s的角膜HOA呈明显的上升曲线，眨眼后HOA增加。瑞巴派特治疗4周后，眨眼后角膜HOA明显改善（P < 0.05），角膜HOA模式稳定。治疗后2周和4周泪膜BUT显著增加（两组比较P < 0.001）。结论：瑞巴派特治疗短BUT型干眼症由于泪液稳定性的改善而显著改善了光学质量。
Purpose: To determine the effect of rebamipide ophthalmic suspension on optical quality in patients with dry eye with short break-up time (BUT) of the tear film.Methods: Twenty-six eyes of 16 patients with the short BUT type of dry eye were enrolled and treated with 2% rebamipide ophthalmic suspension. At baseline and at 2 and 4 weeks after initiating the treatment, the serial corneal higher-order aberrations (HOAs), BUT, fluorescein staining, and Schirmer test were measured. Patients were asked to complete questionnaires about the changes in dry eye-related ocular symptoms after the treatment.Results: Before the treatment, the pattern of postblink corneal HOAs for 10 seconds showed a sawtooth pattern, with a marked upward curve that increased after blinking. Treatment with rebamipide for 4 weeks significantly (P < 0.05) improved the postblink corneal HOAs and stabilized the pattern of the corneal HOAs. Significant increases in the tear film BUT were seen 2 and 4 weeks after the treatment (P < 0.001 for both comparisons).Conclusions: Rebamipide administered to treat the short BUT type of dry eye significantly improved optical quality because of the improvement in tear stability.