ENERGETIC COUPLING BETWEEN DNA BENDING AND BASE PAIR OPENING
ENERGETIC COUPLING BETWEEN DNA BENDING AND BASE PAIR OPENING
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DOI：
10.1073/pnas.85.19.7231
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发表时间：
1988-10-01
影响因子：
11.1
通讯作者：
LAVERY, R
中科院分区：
文献类型：
--
作者：
RAMSTEIN, J;LAVERY, R
通过理论分子模拟研究了B-DNA双链体内碱基对开放的途径。结果表明，单碱基对的破坏与氢交换测量的推论在能量上是相容的。此外，发现DNA弯曲极大地促进了打开过程，并且相反地，一旦碱基对被破坏，DNA可以非常容易地弯曲。看来，这两个过程之间的能量耦合可能在许多涉及核酸畸变的生物反应中发挥重要作用。
The pathway for base pair opening within a B-DNA duplex is investigated by theoretical molecular modeling. The results show that the disruption of a single base pair is energetically compatible with the deductions made from hydrogen exchange measurements. In addition, it is found that the opening process is greatly facilitated by DNA bending and that, conversely, once a base pair is disrupted, DNA can bend very easily. It appears that the energetic coupling between these two processes may play an important role in many biological reactions involving nucleic acid distortion.