Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells
Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells
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DOI：
10.1093/jac/46.1.57
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发表时间：
2000-07-01
影响因子：
5.2
通讯作者：
Ballet, JJ
中科院分区：
文献类型：
--
作者：
Gargala, G;Delaunay, A;Ballet, JJ
在定量碱性磷酸酶免疫测定中，评价了硝唑尼特及其代谢产物替唑尼特和替唑尼特葡萄糖醛酸苷对分化的人肠细胞HCT-8中微小隐孢子虫无性和有性阶段发育的影响。当在子孢子侵入后加入时，硝唑尼特、替唑尼特和替唑尼特葡萄糖醛酸苷具有长达46 h的抑制作用（MIC 50分别为1.2、22.6和2.2 mg/L）。替唑尼特只有有限的活动，但硝唑尼特和替唑尼特葡糖苷酸强烈抑制无性和有性阶段，分别。
The effects of nitazoxanide and its metabolites, tizoxanide and tizoxanide glucuronide, on the development of the asexual and sexual stages of Cryptosporidium parvum in differentiated human enterocytic HCT-8 cells were evaluated in a quantitative alkaline phosphatase immunoassay. Nitazoxanide, tizoxanide and tizoxanide glucuronide were inhibitory for up to 46 h when added after sporozoite invasion (MIC50 1.2, 22.6 and 2.2 mg/L, respectively). Tizoxanide had only limited activity, but nitazoxanide and tizoxanide glucuronide strongly inhibited asexual and sexual stages, respectively.