EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS .2. EFFECT OF DEXAMETHASONE IN GLAUCOMATOUS EYE
EFFECT OF CORTICOSTEROIDS ON INTRAOCULAR PRESSURE AND FLUID DYNAMICS .2. EFFECT OF DEXAMETHASONE IN GLAUCOMATOUS EYE
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DOI：
10.1001/archopht.1963.00960050494011
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发表时间：
1963-01-01
影响因子：
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通讯作者：
ARMALY, MF
中科院分区：
文献类型：
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作者：
ARMALY, MF
本文报道了地塞米松局部应用对高血压性开角型青光眼和低眼压性青光眼患者眼压及眼压动力学的影响。在可比的年龄组中，地塞米松引起的高血压在青光眼患者中总是明显高于正常眼。在低血压性青光眼和高血压开角型青光眼中，两者的变化幅度相同。地塞米松所致高血压对降压药物治疗有效。另一方面，有效的降压治疗不能保护青光眼免受地塞米松的影响。地塞米松在低压性青光眼中的作用表明，小梁网的改变类似于高血压开角型青光眼，揭示了这两种疾病的基本相似之处。讨论了这些发现的实际意义和临床意义，以及为全面了解地塞米松对眼压的影响所需的研究。
In this presentation, the effect of topical application of dexamethasone on intraocular pressure and its dynamics in hypertensive open-angle glaucoma and in low-tension glaucoma was reported. In comparable age groups, the dexamethasone-induced hypertension was always markedly greater in the glaucomatous than in the normal eye. It was of equal magnitude in low tension and in hypertensive open-angle glaucoma. The dexamethasone induced hypertension was responsive to hypotensive medical therapy. On the other hand, effective hypotensive therapy could not protect the glaucomatous eye from the dexamethasone effect. The dexamethasone effect in low tension glaucoma showed that the trabecular meshwork is altered in a manner similar to that of hypertensive open-angle glaucoma, revealing the intimate basic simi[long dash]larity of the 2 disease categories. The practical implications and the clinical significance of these findings, as well as the studies necessary for the complete understanding of the dexamethasone effect on intraocular pressure were discussed.