Variation in gene expression patterns in follicular lymphoma and the response to rituximab
Variation in gene expression patterns in follicular lymphoma and the response to rituximab
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DOI：
10.1073/pnas.0437875100
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发表时间：
2003-02-18
影响因子：
11.1
通讯作者：
Levy, R
中科院分区：
文献类型：
--
作者：
Bohen, SP;Troyanskaya, OG;Levy, R
对 24 名患者滤泡性淋巴瘤基因表达模式的分析表明，可以区分两组肿瘤。所有在任何治疗前进行活检的患者均接受利妥昔单抗治疗，利妥昔单抗是一种针对 B 细胞抗原 CD20 的单克隆抗体。随后对利妥昔单抗无效的肿瘤中的基因表达模式似乎与正常淋巴组织的基因表达模式更相似，而不是与利妥昔单抗应答者的肿瘤的基因表达模式更相似。这些发现表明滤泡性淋巴瘤对利妥昔单抗治疗的反应可以根据肿瘤的基因表达模式来预测。
Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.