Myocardial cavitational activity during continuous infusion and bolus intravenous injections of perfluorocarbon-containing microbubbles
Myocardial cavitational activity during continuous infusion and bolus intravenous injections of perfluorocarbon-containing microbubbles
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DOI：
10.1067/mje.2001.112750
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发表时间：
2001-06-01
影响因子：
6.5
通讯作者：
Xie, E
中科院分区：
文献类型：
--
作者：
Porter, TR;Everbach, C;Xie, E
在用1.7 MHz谐波换能器进行超声处理期间，在静脉输注或注射含氟碳化合物的微泡期间记录了开胸犬前心肌内惯性空化产生的宽带噪声的20 MHz分量。即使在机械指数为0.2时，心肌内空化活动也很明显，但随着帧频和机械指数的增加，空化活动显著增加。微泡产生的心肌对比强度的量通过减少空化活动的变量增加（例如，将每个心动周期的帧速率降低至1或降低机械指数）。在机械指数为0.2时，在10 Hz帧频下仍可观察到心肌对比度。这些结果证实，心肌内空化活动是存在于微泡的超声成像过程中;成像技术，减少空化活动增加心肌对比度的幅度。
The 20-MHz component of broadband noise from inertial cavitation within the anterior myocardium of an open-chest dog was recorded during intravenous infusions or injections of perfluorocarbon-containing microbubbles during insonation with a 1.7-MHz harmonic transducer. Intramyocardial cavitational activity was evident even at a mechanical index of 0.2, but it increased significantly as frame rate and mechanical index were increased. The amount of myocardial contrast intensity produced by the microbubbles was increased by variables that reduced cavitational activity (eg, reducing frame rate to 1 every cardiac cycle or decreasing mechanical index). At a mechanical index of 0.2, myocardial contrast could still be observed at 10-Hz frame rates. These results confirm that intramyocardial cavitational activity is present during ultrasound imaging of microbubbles; imaging techniques that reduce cavitational activity increase the magnitude of myocardial contrast.