Full-length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients.
Full-length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients.
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DOI：
10.1111/jth.15695
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发表时间：
2022-06
期刊：
影响因子：
--
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中科院分区：
文献类型：
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Skeletal muscle myosin (SkM) molecules are procoagulant both in vitro and in vivo. The association of plasma SkM isoforms with blood coagulability and hemostatic capacity has not been defined. We hypothesized that coagulopathy in acutely injured patients is associated with procoagulant plasma SkM heavy chain levels. To test this hypothesis, citrated whole blood and plasma from 104 trauma patients were collected and studied to obtain data for rapid thrombelastography, international normalized ratios, and plasma SkM levels. Coagulability parameters were dichotomized by the threshold for the hypercoagulable trauma‐induced coagulopathy. Lower plasma full‐length SkM heavy chain (full‐SkM) levels were associated with higher international normalized ratio values (>1.3) (p = .03). The full‐SkM levels were also associated with a lower rate of clot propagation (thrombelastography angle <65°) (p = .004), and plasma full‐SkM levels were positively correlated with the thrombelastography angle (r 2 = .32, p = .0007). The trauma patient group with the lower plasma full‐SkM levels showed an association with lower clot strength (maximum amplitude <55 mm) (p = .002), and plasma full‐SkM levels positively correlated with maximum amplitude (r 2 = .27, p = .005). Hyperfibrinolysis was associated with significantly decreased full‐SkM levels (p = .03). Trauma patients who required red blood cells and fresh frozen plasma transfusions had lower plasma full‐SkM levels compared with those without transfusions (p = .04 and .02, respectively). In acutely injured trauma patients, lower levels of plasma full‐SkM levels are linked to hypocoagulability in trauma‐induced coagulopathy, implying that SkM plays a role in the hemostatic capacity in trauma patients and may contribute to trauma‐induced coagulopathy.
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DOI：
10.1097/ta.0000000000001270
发表时间：
2017-01
期刊：
The journal of trauma and acute care surgery
影响因子：
--
作者：
Einersen PM;Moore EE;Chapman MP;Moore HB;Gonzalez E;Silliman CC;Banerjee A;Sauaia A
通讯作者：
Sauaia A
影响因子：
--
作者：
LOFBERG, M;TAHTELA, R;SOMER, H
通讯作者：
SOMER, H
DOI：
10.1161/atvbaha.120.313990
发表时间：
2020-04-01
影响因子：
8.7
作者：
Zilberman-Rudenko, Jevgenia;Deguchi, Hiroshi;Griffin, John H.
通讯作者：
Griffin, John H.
影响因子：
5
作者：
Erlacher, P;Lercher, A;Mair, J
通讯作者：
Mair, J
影响因子：
3.4
作者：
Chapman, Michael P.;Moore, Ernest E.;Sauaia, Angela
通讯作者：
Sauaia, Angela