Logical design of medical chaperone for prion diseases.
Logical design of medical chaperone for prion diseases.
复制标题
朊病毒疾病医疗伴侣的逻辑设计。
DOI：
10.2174/15680266113136660171
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发表时间：
2013
影响因子：
3.4
通讯作者：
K. Kuwata
中科院分区：
文献类型：
--
作者：
K. Kuwata
综述了逻辑药物设计策略及其在朊病毒疾病中的应用。LDD主要基于热点的定位性，该热点引发靶蛋白中的结构不稳定性。它还基于小化合物对热点的可调节性、计算机对它们的可设计性、它们的有机合成性以及一旦被施用到生物有机体上它们的功能的特异性。地方性、可调控性、可生产性和特殊性的统一是地方性开发的中心思想。初步概述了LDD的量子理论基础。使用核磁共振（NMR）的本地化，由医疗伴侣的调节性，合成性，和功能特异性完成迄今为止，然后描述。
A strategy of logical drug design (LDD) and its application to prion diseases are reviewed. LDD is primarily based on the localizability of a hot spot which initiates structural instability in the target protein. It is also based on the regulability of the hot spot by small compounds, their designabilty by a computer, their organic synthesizability and the specificity of their functions once administered to the biological organisms. Unification of localizability, regulability, producibility and specificity is the central theme of LDD. Theoretical foundation of LDD based on quantum theories is initially outlined. The localizability using nuclear magnetic resonance (NMR), the regulability by a medical chaperone, the synthesizability, and the functional specificity accomplished thus far, are then described.