Vagal Nerve Stimulation for Pulmonary Hypertension: Some Promise, Some Skepticism.
Vagal Nerve Stimulation for Pulmonary Hypertension: Some Promise, Some Skepticism.
复制标题
迷走神经刺激治疗肺动脉高压：有些许诺，有些怀疑。
DOI：
10.1016/j.jacbts.2018.09.002
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Greif,DanielM
中科院分区：
文献类型：
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作者：
Ntokou,Aglaia;Greif,DanielM
Pulmonary hypertension (PH) or elevated blood pressure in the pulmonary vasculature is a serious disease entity in its own right and a grave complication of other disorders. PH is divided into 5 classes by the World Health Organization. Class 1, or pulmonary artery hypertension (PAH), includes PH due to idiopathic, heritable, and genetic causes, as well as drugs, toxins, and some connective tissue diseases and infections. Unfortunately, PAH is lethal, with one-half of all patients dying within 7 years of their initial diagnosis (1). The pathophysiology of PH is complex, with an intricate interplay among diverse cell types, including smooth muscle cells, endothelial cells, fibroblasts, inflammatory cells, and neurons (2–6). Undoubtedly, this complexity contributes to the difficulty in devising therapies to substantially improve the clinical course of patients with PAH.
