Orthology, Function and Evolution of Accessory Gland Proteins in the Drosophila repleta Group
Orthology, Function and Evolution of Accessory Gland Proteins in the Drosophila repleta Group
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DOI：
10.1534/genetics.108.096263
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发表时间：
2009-01-01
期刊：
影响因子：
3.3
通讯作者：
DeSalle, Rob
中科院分区：
文献类型：
--
作者：
Almeida, Francisca C.;DeSalle, Rob
果蝇的副腺蛋白（Acps）已成为研究生殖蛋白进化的一个模型。Acps研究的一个主要步骤是通过比较具有不同生物学特性的物种群来确定所观察到的分子进化模式的生物学原因和后果。在这里，我们描述了果蝇的Acp补体，一个充满群的代表。与其他种类的果蝇相比，这一类群在生态和繁殖方面表现出重要的差异。我们的研究结果表明，以前发现的Acp的极高进化率可能在充满群体的物种中普遍存在。这些进化速度比在其他果蝇群体的Acps中观察到的要高得多。然而，这种差距并不存在。同时，如先前所建议的，在副署长的估计数目或所代表的职能类别方面存在重大差异。在1)副腺中表达的基因中，几乎有一半可能是最近复制的产物。这使我们能够在或多或少受限的时间尺度内预测基因复制和平行进化的新功能化模型。我们发现，在这些基因对的早期分化中，正选择是一种强大的力量。
The accessory gland proteins (Acps) of Drosophila have become a model for the study of reproductive protein evolution. A major step in the study of Acps is to identify biological causes and consequences of the observed patterns of molecular evolution by comparing species groups with different biology. Here we characterize the Acp complement of Drosophila mayaguana, a repleta group representative. Species of this group show important differences in ecology and reproduction as compared to other Drosophila. Our results Show that the extremely high rates of Acp evolution previously found are likely to be ubiquitous among species of the replete group. These evolutionary rates are considerably higher than the ones observed in other Drosophila groups' Acps. This disparity, however, is not. accompanied by major differences in the estimated number of Acps or in the functional categories represented as previously suggested. Among the genes expressed in accessory glands of 1). mayaguana almost half are likely products of recent duplications. This allowed us to lest predictions of the neofunctionalization model for gene duplication and paralog evolution in a more or less constrained timescale. We found that positive selection is a strong force in the early divergence of these gene pairs.