An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
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DOI：
10.4161/onci.24461
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发表时间：
2013-06-01
期刊：
影响因子：
7.2
通讯作者：
Hagemann T
中科院分区：
文献类型：
--
作者：
Neyen C;Mukhopadhyay S;Gordon S;Hagemann T
肿瘤相关巨噬细胞向M2表型迁移并表达清道夫受体A（SRA），从而促进肿瘤进展。我们证明了SRA可以用小肽抑制剂4F在体内治疗靶向以防止转移扩散。在我们的研究之外，4F正在成为一种有前途的抗癌药物。
Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.