Effects of long term intravenous administration of ethanol on rat pancreas.
Effects of long term intravenous administration of ethanol on rat pancreas.
复制标题
长期静脉注射乙醇对大鼠胰腺的影响。
DOI：
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发表时间：
1983
影响因子：
2.2
通讯作者：
T. Sato
中科院分区：
文献类型：
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作者：
S. Matsuno;K. Kano;K. Miyagawa;H. Yamauchi;T. Sato
研究人员每天通过口服或静脉途径接受乙醇溶液，或通过静脉途径接受等热量剂量的葡萄糖溶液，持续 4 周，研究大鼠的胰腺外分泌功能和形态变化。在口服乙醇组和静脉注射乙醇组中观察到了相当程度的外分泌功能障碍和胰腺超微结构水平的形态变化。注射乙醇，这表明酒精发挥其胰腺毒性作用不需要胃内摄入或高血液浓度。所有接受乙醇或葡萄糖的大鼠组均表现出营养障碍的体征和病理结果，并且在治疗4周时，口服乙醇组的胰腺电子显微镜异常更加明显且发生率更高。或静脉注射比给予静脉注射的组葡萄糖的剂量。口服乙醇 18 个月后，大鼠胰管系统起源区域没有出现蛋白质堵塞或其他变化的微观证据。目前的研究结果表明，酒精对腺泡细胞的细胞毒性作用以及与酒精摄入相关的营养障碍是慢性酒精性胰腺炎发病机制的重要因素。
Pancreatic exocrine function and morphologic changes were investigated in groups of rats receiving solutions of ethanol by oral or intravenous route, or equicaloric doses of glucose solution by intravenous route daily for a period of 4 weeks. Comparable degrees of exocrine dysfunction and morphologic changes in the pancreas at the ultrastructural level were observed in the groups given ethanol orally and in those receiving i.v. injections of ethanol, suggesting that neither intragastric ingestion nor high blood levels of alcohol is required for alcohol to exert its pancreatotoxic effects. All groups of rats receiving ethanol or glucose showed signs and pathologic findings of nutritional disorder, and at 4 weeks of treatment, electron microscopic abnormalities of the pancreas were more pronounced and higher in incidence in the groups given ethanol p.o. or i.v. than in the groups given i.v. doses of glucose. There was no microscopic evidence of protein plug or other changes in the region of origin of the pancreatic duct system in rats after 18 months of oral administration of ethanol. The present findings indicate that the cytotoxic effect of alcohol on acinar cells and nutritional disorder associated with alcohol ingestion constitute important factors in the pathogenesis of chronic alcoholic pancreatitis.