Formation of organic nanoparticles from volatile microemulsions
Formation of organic nanoparticles from volatile microemulsions
复制标题
DOI：
10.1016/j.jcis.2009.10.024
复制
发表时间：
2010-02-15
影响因子：
9.9
通讯作者：
Magdassi, Shlomo
中科院分区：
文献类型：
--
作者：
Margulis-Goshen, Katrin;Netivi, Hadas Donio;Magdassi, Shlomo
提出了一种制备水溶性差的有机材料纳米颗粒的方法。通过该方法，含有挥发性溶剂和溶解的模型材料对羟基苯甲酸丙酯的水包油微乳液经历溶剂蒸发并通过喷雾干燥转化成纳米颗粒。所得粉末可以容易地分散在水中，以得到具有高负载的对羟基苯甲酸丙酯的纳米颗粒的澄清、稳定的分散体。通过过滤该分散体，发现大于95重量%的分散体是分散的。的.分散的对羟基苯甲酸丙酯为小于450 nm的颗粒。X射线衍射显示，对羟基苯甲酸丙酯以40-70 nm的纳米晶体存在。粉末在水中分散后，迅速形成大晶体。添加聚乙烯吡咯烷酮（PVP）防止粉末在水中分散期间的晶体生长。通过分子动力学模拟研究了PVP对尼泊金丙酯晶体生长的抑制作用。PVP和聚乙烯醇之间进行了比较，没有显示出晶体抑制性能。(C)2009 Elsevier Inc. All rights reserved.
A method for preparation of nanoparticles of poorly water-soluble organic materials is presented. By this method, an oil-in-water microemulsion containing a volatile solvent with dissolved model material, propylparaben, undergoes solvent evaporation and conversion into nanoparticles by spray drying. The resulting powder can be easily dispersed in water to give a clear, stable dispersion of nanoparticles with a high loading of propylparaben. By filtration of this dispersion it was found that more than 95 wt.% of the. dispersed propylparaben is in particles of less than 450 nm. X-ray diffraction revealed that propylparaben is present as nanocrystals of 40-70 nm. After dispersion of the powder in water, formation of large crystals rapidly occurs. Addition of polyvinylpyrrolidone (PVP) prevented crystal growth during dispersion of the powder in water. The inhibition of propylparaben crystal growth by PVP was studied by molecular dynamic simulations that addressed the binding of PVP to the propylparaben crystal. A comparison was made between PVP and polyvinylalcohol, which did not display crystal inhibition properties. (C) 2009 Elsevier Inc. All rights reserved.