Associations of IL-23 with Polypoidal Choroidal Vasculopathy
Associations of IL-23 with Polypoidal Choroidal Vasculopathy
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DOI：
10.1167/iovs.11-7913
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发表时间：
2012-06-01
影响因子：
4.4
通讯作者：
Inoue, Yoshitsugu
中科院分区：
文献类型：
--
作者：
Sasaki, Shin-ichi;Miyazaki, Dai;Inoue, Yoshitsugu
目的。目的：探讨眼内炎性细胞因子水平与息肉样脉络膜血管病变（PCV）的关系。前瞻性队列研究。对62例PCV患者和36例对照组进行了研究。评估了PCV患者和对照组房水样本中细胞因子、趋化因子和生长因子的水平，以确定其与PCV的显著相关性。将研究人群分成四分位数后，采用Logistic回归分析计算比值比（ORs）和95%置信区间（ci）。在PCV患者中，IL-4、IL-10和IL-23明显高于对照组。Logistic分析显示IL-23（最高四分位数与最低四分位数的OR: 16.3; 95% CI: 3.5-75.2）、VEGF（5.7; 1.2-26.1）和IL-4（4.0; 1.3-12.7）的风险显著增高。PCV患者IL-10、IL-4与VEGF水平有显著相关性，IL-23无显著相关性（IL-10: rho = 0.477, IL-4: rho = 0.281）。在荧光素血管造影中发现IL-5、IL-10、IL-4、IL-23和IL-1 α水平升高与渗出性病变显著相关。IL-23水平升高与PCV及其活性之间的显著相关性强烈提示PCV的病因参与炎症过程，可能独立于VEGF。（www.umin.ac.jp/ctr编号，UMIN000003854）（Invest Ophthalmol Vis Sci. 2012;53:3424-3430） DOI:10.1167/iovs.11-7913
PURPOSE. To determine the relationship between the levels of intraocular inflammatory cytokines and polypoidal choroidal vasculopathy (PCV).METHODS. Prospective cohort study. Sixty-two patients with PCV and 36 control subjects were studied. The levels of cytokines, chemokines, and growth factors in the aqueous humor samples from PCV patients and control subjects were assessed for significant associations with PCV. Logistic regression analysis was used to compute the odds ratios (ORs) and 95% confidence intervals (CIs) after the study populations were divided into quartiles.RESULTS. In PCV patients, IL-4, IL-10, and IL-23 were significantly higher than in the controls. Logistic analyses showed a significantly high risk for IL-23 (OR for the highest quartile compared with the lowest quartile: 16.3; 95% CI: 3.5-75.2), VEGF (5.7; 1.2-26.1), and IL-4 (4.0; 1.3-12.7). IL-10 and IL-4, but not IL-23, were significantly correlated with the VEGF levels in PCV patients (IL-10: rho = 0.477, IL-4: rho = 0.281). The elevated levels of IL-5, IL-10, IL-4, IL-23, and IL-1 alpha were found to be significantly associated with exudative lesion(s) in the fluorescein angiograms.CONCLUSIONS. The significant associations between elevated levels of IL-23 with PCV and its activity strongly suggest an involvement of inflammatory processes in the etiology of PCV, presumably independent of VEGF. (www.umin.ac.jp/ctr number, UMIN000003854.) (Invest Ophthalmol Vis Sci. 2012;53:3424-3430) DOI:10.1167/iovs.11-7913