Local hyperthermia and irradiation in cancer therapy.
Local hyperthermia and irradiation in cancer therapy.
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癌症治疗中的局部热疗和照射。
DOI：
10.1080/16070658.1981.11689240
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
C. Perez
中科院分区：
文献类型：
--
作者：
C. Perez
初步的经验，在Mallinckrodt研究所的放射热疗和辐射的报告和当前的问题，在临床应用中的热量进行审查。每72小时（每周两次）给予400 rad分次，总剂量为2400至4000 rad，然后进行热疗（1450 MHz或915 MHz微波，42.0度-43度，90分钟，每72小时）。12例复发性头颈部表皮样癌中有8例完全消退（67%），1例缓解率超过50%。在5个转移性黑色素瘤结节中，4个（80%）显示肿瘤完全消退，1个几乎完全缓解。9例胸壁复发性乳腺癌结节经3200 ~ 4000 rad治疗后，5例完全消退，2例消退约80%。6个病灶用1500拉德和热疗（RTOG方案）治疗，2个转移性黑色素瘤显示完全消退（CR），3个肿瘤显示部分消退。在治疗的35个部位中，4个（11%）出现水疱，7个（20%）仅出现红斑，3个（8%）出现湿性脱屑，27个（77%）出现干性脱屑。其他临床试验正在进行中，以评估单独使用热疗或联合放射治疗选定的癌症患者的潜在价值。
The preliminary experience at the Mallinckrodt Institute of Radiology with hyperthermia and irradiation is reported and current issues in clinical application of heat are reviewed. Twenty-nine lesions were treated with 400 rad fractions given every 72 hr (twice weekly) for a total dose of 2400 to 4000 rad followed by hyperthermia (1450-MHz or 915-MHz microwaves, 42.0 degrees -43 degrees, 90 min, every 72 h). Eight of 12 recurrent epidermoid carcinomas of the head and neck showed complete regression (67%) and one more than 50% response. Of 5 metastatic melanoma nodules treated with irradiation an hyperthermia, 4 (80%) showed complete regression of the tumors an 1 almost complete response. Of 9 recurrent adenocarcinoma of breast nodules in the chest wall treated with 3200 to 4000 rad 5 lesions exhibited complete regression and 2 others about 80%. Of 6 lesions treated with 1500 rad and hyperthermia (RTOG protocol), 2 metastatic melanomas showed complete regression (CR) and 3 tumors exhibited partial regression. Of the 35 sites treated, 4 (11%) developed blisters, 7 (20%) erythema only, 3 (8%) moist desquamation and 27 (77%) dry desquamation. Additional clinical trials are in progress to assess the potential value of hyperthermia alone or combined with irradiation in the treatment of selected cancer patients.
DOI：
10.1016/0360-3016(80)90325-9
发表时间：
1980
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Bicher,HI;Sandhu,TS;Hetzel,FW
通讯作者：
Hetzel,FW