New insights into the structure and function of the plasminogen/plasmin system
New insights into the structure and function of the plasminogen/plasmin system
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DOI：
10.1016/j.sbi.2013.10.006
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发表时间：
2013-12-01
影响因子：
6.8
通讯作者：
Whisstock, James C.
中科院分区：
文献类型：
--
作者：
Law, Ruby H. P.;Abu-Ssaydeh, Diana;Whisstock, James C.
Plasminogen is the zymogen form of plasmin, an enzyme that plays a fundamental role in the dissolution of fibrin clots, the extracellular matrix and other key proteins involved in immunity and tissue repair. Comprising seven distinct domains (an N-terminal Pan-apple domain (PAp), 5 kringle domains (KR) and the serine protease domain (SP)), plasminogen undergoes a complex, incompletely understood conformational change that is key to its activation. Here, we review our current understanding of the structural basis for plasminogen activation with regard to new insights derived from crystallographic and biochemical studies.
