Development of Monoclonal Antibodies: The Dawn of mAb Rule.
Development of Monoclonal Antibodies: The Dawn of mAb Rule.
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单克隆抗体的开发：单克隆抗体规则的黎明。
DOI：
10.1007/s10620-017-4478-1
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发表时间：
2017
影响因子：
3.1
通讯作者：
Kaunitz,JonathanD
中科院分区：
文献类型：
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作者：
Kaunitz,JonathanD
大多数重大治疗进展的基础是根本性的发现，这些发现动摇了科学话语的核心，通常会产生诺贝尔奖和全新的研究领域。在本系列的第八期中，索非亚博士和鲁宾博士强调了治疗性单抗(MAbbs)对胃肠道实践的巨大影响。抗体的发展历史可以追溯到18世纪，当时他们发现，当被注射到接受者体内时，从天花脓疮中获得的液体可以提供对感染这种疾病的免疫力。爱德华·詹纳以使用牛痘脓疱液来免疫天花而闻名，他推进了这些研究。抗体的发现可以追溯到冯·贝林和北里，他们在1890年发表了里程碑式的发现，将白喉免疫动物的血清转移到感染白喉的动物身上，改变了疾病的进程。展望二十世纪，Paul Ehrlich和Emil Fischer在抗体构型方面的开创性工作对当前对抗体结构的理解具有显著的预测作用。1972年，诺贝尔奖被授予杰拉尔德·埃德尔曼和罗德尼·波特，以表彰他们对抗体化学结构的理解做出的贡献。
Underlying most major therapeutic advances are fundamental discoveries that shake scientific discourse to its core, usually generating Nobel prizes and entirely new fields of study. In this eighth installment of the series entitled ‘‘Paradigm Shifts in Perspective,’’Drs. Sofia and Rubin highlight the considerable impact that therapeutic monoclonal antibodies (mAbs) have made on gastrointestinal practice.The history of antibody development can be traced back to the eighteenth century, with the discovery that fluid obtained from a smallpox pustule when injected into a recipient provided immunity from acquiring the disease. Edward Jenner, who famously used fluid from cowpox pustules to immunize against smallpox, advanced these studies. The discovery of antibodies can be traced to von Behring and Kitasato, who in 1890 published the landmark finding that transfer of serum from animals that had been immunized to diphtheria to animals infected with diphtheria altered the course of the disease. Going forward to the twentieth century, the pioneering work of Paul Ehrlich and Emil Fischer regarding antibody configuration was remarkably predictive of the current understanding of antibody structure. The Nobel Prize was awarded in 1972 to Gerald Edelman and Rodney Porter for their contributions to the understanding of the chemical structure of antibodies.