CDNA SEQUENCE OF HUMAN APOLIPOPROTEIN(A) IS HOMOLOGOUS TO PLASMINOGEN
CDNA SEQUENCE OF HUMAN APOLIPOPROTEIN(A) IS HOMOLOGOUS TO PLASMINOGEN
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DOI：
10.1038/330132a0
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发表时间：
1987-11-12
期刊：
影响因子：
64.8
通讯作者：
LAWN, RM
中科院分区：
文献类型：
--
作者：
MCLEAN, JW;TOMLINSON, JE;LAWN, RM
脂蛋白(a)是一种类LDL脂蛋白，其血浆浓度与动脉粥样硬化相关。脂蛋白(a) 的特征蛋白质成分是载脂蛋白(a)，它通过二硫键与载脂蛋白B-100 连接。克隆的人载脂蛋白（a）互补 DMA 的测序表明，它与人纤溶酶原非常相似。它包含一个丝氨酸蛋白酶结构域和两种类型的纤溶酶原样 kringle 结构域，其中一种存在 37 个拷贝。
Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DMA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.