Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds.
Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds.
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来自野鸟的新型重配 H10N5 流感病毒的遗传特性和致病性。
DOI：
10.1007/s00705-017-3234-3
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Zhu Qiyun
中科院分区：
文献类型：
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作者：
Jia Yane;Yang Jiayun;Wang Zhengxiang;Du Yingying;Cui Jie;Wang Liang;Guo Fengfeng;Yang Maijuan;Han Shufang;Zhu Qiyun
在这项研究中，我们分析了野生鸟类H10 N5流感病毒的基因组。该病毒被鉴定为具有来自多个亚型和不同来源的内部基因的新型重组病毒。在小鼠中连续传代后，产生了携带突变PB 2-E627 K和HA-G218 E的小鼠适应性病毒。这些病毒引起了鸡体重的急剧下降和死亡，并在小鼠脑中复制，表明低致病性H10 N5在哺乳动物中传代后可增强其对鸡的致病性。我们的数据表明，H10 N5病毒可能对人类健康构成潜在风险，因此必须对这些病毒进行持续监测和生物安全评估。
In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses.