The Microbead: A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System
The Microbead: A Highly Miniaturized Wirelessly Powered Implantable Neural Stimulating System
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DOI：
10.1109/tbcas.2018.2802443
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发表时间：
2018-06-01
影响因子：
5.1
通讯作者：
Etienne-Cummings, Ralph
中科院分区：
文献类型：
--
作者：
Khalifa, Adam;Karimi, Yasha;Etienne-Cummings, Ralph
目前还不存在可以电刺激大脑不同深度和区域的神经元的植入物，因为它构成了许多需要解决的障碍。为了应对这些挑战，本文提出了“微珠”的概念，这是一种完全集成的无线供电神经设备，允许空间选择性激活神经组织。原型芯片是在130纳米CMOS技术制造，目前的措施200亩米× 200亩米，这是迄今为止最小的远程供电刺激器。该系统是在大鼠实验验证刺激坐骨神经与195 μ s的电流脉冲。为了给超小型硅线圈供电，在5 mm的耦合距离处向高度优化的发射器（Tx）线圈提供36 dBm的源功率。为了满足用于人类受试者安全使用的严格功率限制，实施脉冲供电方案，该方案使得从Tx发射的平均功率显著降低。
An implant that can electrically stimulate neurons across different depths and regions of the brain currently does not exist as it poses a number of obstacles that need to be solved. In order to address the challenges, this paper presents the concept of "microbead," a fully integrated wirelessly powered neural device that allows for spatially selective activation of neural tissue. The prototype chip is fabricated in 130-nm CMOS technology and currently measures 200 mu m x 200 mu m, which represents the smallest remotely powered stimulator to date. The system is validated experimentally in a rat by stimulating the sciatic nerve with 195-mu s current pulses. To power the ultrasmall on-silicon coil, 36-dBm source power is provided to a highly optimized transmitter (Tx) coil at a coupling distance of 5 mm. In order to satisfy the strict power limit for safe use in human subjects, a pulsed powering scheme is implemented that enables a significant decrease in the average power emitted from the Tx.