Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
复制标题
DOI：
10.1016/j.cell.2013.02.053
复制
发表时间：
2013-04-11
期刊：
影响因子：
64.5
通讯作者：
Chawla A
中科院分区：
文献类型：
--
作者：
Heredia JE;Mukundan L;Chen FM;Mueller AA;Deo RC;Locksley RM;Rando TA;Chawla A
在脊椎动物中，先天免疫的激活是对损伤的早期反应，这意味着它参与了再生过程。然而，先天信号调控干细胞功能的机制尚不清楚。在这里，我们证明2型先天免疫是骨骼肌损伤后再生所必需的。肌肉损伤导致嗜酸性粒细胞的快速募集，其分泌IL-4来激活肌肉常驻纤维/脂肪细胞祖细胞（FAPs）的再生作用。在FAPs中，IL-4/IL-13信号是控制FAPs命运和功能的关键开关。IL-4/IL-13信号的激活促进FAPs的增殖以支持肌肉形成，同时抑制它们向脂肪细胞的分化。令人惊讶的是，FAPs（而非髓细胞）也需要2型细胞因子信号来快速清除坏死碎片，这是组织及时和完全再生所必需的过程。
In vertebrates, activation of innate immunity is an early response to injury, implicating it in the regenerative process. However, the mechanisms by which innate signals might regulate stem cell functionality are unknown. Here we demonstrate that type 2 innate immunity is required for regeneration of skeletal muscle after injury. Muscle damage results in rapid recruitment of eosinophils, which secrete IL-4 to activate the regenerative actions of muscle resident fibro/adipocyte progenitors (FAPs). In FAPs, IL-4/IL-13 signaling serves as a key switch to control their fate and functions. Activation of IL-4/IL-13 signaling promotes proliferation of FAPs to support myogenesis, while inhibiting their differentiation into adipocytes. Surprisingly, type 2 cytokine signaling is also required in FAPs, but not myeloid cells, for rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues.
登录
查看更多内容
DOI：
10.1084/jem.20120295
发表时间：
2012-03-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Karp CL;Murray PJ
通讯作者：
Murray PJ
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
11.8
作者：
Conboy, IM;Rando, TA
通讯作者：
Rando, TA
过敏宿主防御。
影响因子：
64.8
作者：
Palm, Noah W.;Rosenstein, Rachel K.;Medzhitov, Ruslan
通讯作者：
Medzhitov, Ruslan
影响因子：
4.4
作者：
Lucas, Tina;Waisman, Ari;Eming, Sabine A.
通讯作者：
Eming, Sabine A.