Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization
Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization
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DOI：
10.1245/aso.2003.04.021
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发表时间：
2003-04-01
影响因子：
3.7
通讯作者：
Osborne, M
中科院分区：
文献类型：
--
作者：
Simmons, R;Thevarajah, S;Osborne, M
工作背景：方法：回顾性分析112例乳腺癌患者（113个腋窝）行前哨淋巴结活检（SLNB）的临床资料。所有SLN均进行术中冰冻切片分析、苏木精-伊红染色和免疫组化评价。结果：112例SLNB患者中，SLN检出率为95.5%（107/112），亚甲蓝染色检出率为92.8%（104/112）。在99例记录了与蓝色淋巴结相关的同位素状态的患者的子集中，在94例（94.9%）中观察到染料和同位素的一致识别。在确定的SLN患者中，32/107（29.9%）包含转移性疾病，其中31/32（96.9%）通过亚甲蓝染料确定。结论：亚甲蓝染色SLNB是一种有效的替代异硫兰染色的方法，可以准确地识别乳腺癌患者的SLN。
Background: Our study describes the use of methylene blue dye as an alternative to isosulfan blue dye to identify the sentinel lymph node (SLN).Methods: A retrospective analysis was performed of 112 breast cancer patients (113 axillae) who underwent SLN biopsy (SLNB) with methylene blue dye and Tc-99m-labeled sulfur colloid for SLN identification. All SLNs were submitted for intraoperative frozen section analysis, hematoxylin and eosin stain, and immunohistochemical evaluation. Patients with a pathologically negative SLN did not undergo further axillary lymph node dissection.Results: Of 112 patients who underwent SLNB, the SLN was identified in 107 (95.5%); 104 (92.8%) were identified by methylene blue dye. In a subset of 99 patients with recorded isotope status in relation to blue nodes, concordant identification with both dye and isotope was observed in 94 (94.9%). Of patients with identified SLNs, 32 (29.9%) of 107 contained metastatic disease, with 31 (96.9%) of 32 identified by methylene blue dye. The SLN was the only positive node in 18 (60.0%) of 30 patients.Conclusions: SLNB with methylene blue dye is an effective alternative to isosulfan blue dye for accurately identifying SLNs in breast cancer patients.