FIBROBLAST GROWTH-FACTOR INFLUENCES THE DEVELOPMENT AND CYCLING OF MURINE HAIR-FOLLICLES
FIBROBLAST GROWTH-FACTOR INFLUENCES THE DEVELOPMENT AND CYCLING OF MURINE HAIR-FOLLICLES
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DOI：
10.1006/dbio.1993.1091
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发表时间：
1993-04-01
影响因子：
2.7
通讯作者：
DUCROS, DL
中科院分区：
文献类型：
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作者：
DUCROS, DL
观察了碱性成纤维细胞生长因子（bFGF）对新生小鼠皮肤毛囊发育的影响。新生小鼠（B6 C3系）每天皮下注射bFGF和牛血清白蛋白（BSA），持续7天。到第9天，在bFGF治疗部位周围观察到明显的无毛、无色素皮肤区域。这种现象一直持续到大约14-16天的年龄时，出现的头发在秃头补丁首次看到。毛发在处理区域中继续生长，直到它们在出生后18-20天大部分被覆盖。在所有年龄，仅注射BSA的对照部位与周围色素沉着的多毛皮肤无法区分。对不同年龄的bFGF治疗小鼠的皮肤进行组织学检查表明，生长因子影响了毛囊的起始和发育。与仅注射BSA的对照动物相比，这导致第一个和随后的毛发周期显著延迟。
The effects of basic fibroblast growth factor (bFGF) on the development of hair follicles in neonatal mouse skin were examined. Newborn mice (B6C3-based strain) were given daily subcutaneous injections of bFGF and bovine serum albumin (BSA) for 7 days. By Day 9, distinct areas of hairless, unpigmented skin were observed surrounding the sites treated with bFGF. This phenomenon persisted until about 14-16 days of age when the emergence of hair in the bald patches was first seen. Hair growth continued in the treated regions until they were mostly covered at 18-20 days of postnatal age. Control sites injected with BSA only were indistinguishable from the surrounding pigmented, hairy skin at all ages. Histological examination of skin from various ages of bFGF-treated mice suggested that the growth factor had affected both the initiation and the development of the hair follicles. This resulted in a significant delay in the first and subsequent hair cycles when compared to control animals injected with BSA only.