Immunological studies in methadone maintained patients.
Immunological studies in methadone maintained patients.
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对美沙酮维持患者进行的免疫学研究。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
M. Grieco
中科院分区：
文献类型：
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作者：
P. Cushman;S. Gupta;M. Grieco
对30例美沙酮维持毒品依赖者外周血T淋巴细胞和B淋巴细胞形成的玫瑰花进行比较。30例患者中有6例（20%）发现T型玫瑰花形成细胞比例异常，而B型玫瑰花形成细胞比例增加的占40%，减少的占27%。似乎外周淋巴细胞百分比的改变，特别是那些具有细胞表面补体受体的淋巴细胞百分比的改变，应该被添加到一些美沙酮治疗的麻醉成瘾者明显的免疫异常列表中。
Rosettes formed by circulating T and B lymphocytes obtained from 30 methadone maintained narcotic addicts were compared with those of 23 normal control subjects. Abnormal percentages of T rosette-forming cells were found in 6 of 30 patients (20%) while the percentages of B rosette-forming cells were increased in 40% and reduced in 27% of methadone patients. It appears that alterations in the percentages of peripheral lymphocytes, particularly those with cell surface complement receptors, should be added to the list of immunological abnormalities evident in some methadone-treated narcotic additics.