INFLUENZA IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
INFLUENZA IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
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DOI：
10.1378/chest.98.1.33
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发表时间：
1990-07-01
期刊：
影响因子：
9.6
通讯作者：
MILLS, J
中科院分区：
文献类型：
--
作者：
SAFRIN, S;RUSH, JD;MILLS, J
虽然感染人类免疫缺陷病毒（HIV）的患者可能会因流感病毒感染而比正常人病情更严重，但此类患者的流感病程尚未得到很好的描述。我们描述了六个连续的艾滋病毒感染患者在旧金山弗朗西斯科总医院（加州，美国），其中流感病毒分离诱导痰或支气管肺泡灌洗液标本之间的1988年12月和1989年3月。虽然流感的临床表现和继发性并发症的发生率与健康人群相比没有变化，但我们的比较能力受到样本量小的限制。然而，低氧血症的高患病率和疾病持续时间延长的趋势被确定。需要更大规模的对照研究来确定HIV感染患者与非免疫抑制患者的流感病毒感染过程。
Although patients infected with human immunodeficiency virus (HIV) might be expected to have more severe illness due to influenza virus infection than normal persons, the course of influenza in such patients has not been well delineated. We describe six consecutive HIV-infected patients at San Francisco General Hospital (California, USA) in whom influenza virus was isolated from induced sputum or bronchoalveolar lavage specimens between December 1988 and March 1989. Although neither clinical presentation of influenza nor rate of secondary complications appeared to be altered from that in healthy individuals, our power of comparison was limited by small sample size. However, a high prevalence of hypoxemia and a trend toward prolonged duration of illness were identified. Larger, controlled studies are needed to define the course of influenza virus infection in HIV-infected patients as compared with nonimmunosuppressed patients.