Short-term hypoxia reduces arterial stiffness in healthy men
Short-term hypoxia reduces arterial stiffness in healthy men
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短期缺氧可降低健康男性的动脉僵硬度
DOI：
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发表时间：
2008
影响因子：
3
通讯作者：
R. Grunstein
中科院分区：
文献类型：
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作者：
H. Vedam;C. Phillips;David Wang;D. Barnes;J. Hedner;G. Unger;R. Grunstein
本研究探讨了缺氧（80%动脉氧合血红蛋白饱和度20分钟）和伴随的心率和血压的变化对健康男性动脉僵硬度的两个组成部分的影响。连续测量增强指数（AIx）和反射时间（Tr），分别代表肌性动脉和主动脉僵硬度。首先，受试者暴露于缺氧（n = 12）或室内空气（n = 5）。在早期缺氧期间，AIx在降低至基线之前增加6%。缺氧后AIx进一步下降6%。相反，Tr没有变化。然后，6名受试者在输注一氧化氮（NO）合酶抑制剂NG-单甲基-L-精氨酸（L-NMMA）或生理盐水后暴露于缺氧。缺氧时，AIx下降12%，但L-NMMA后增加14%，Tr无变化。这些结果表明，缺氧可能会导致NO介导的血管扩张的小肌动脉，但不是主动脉。
This study examined the effects of hypoxia (80% arterial oxyhaemoglobin saturation for 20 min) and the accompanying changes in heart rate and blood pressure on two components of arterial stiffness in healthy men. Augmentation index (AIx) and time to reflection (Tr) representing measures of muscular artery and aortic stiffness, respectively, were continuously measured. At first, subjects were exposed to either hypoxia (n = 12) or room air (n = 5). During early hypoxia AIx increased by 6% before decreasing to baseline. After hypoxia AIx decreased by a further 6%. In contrast there was no change in Tr. Six subjects were then exposed to hypoxia following infusion with the nitric oxide (NO) synthase inhibitor NG-mono-methyl-l-arginine (L-NMMA) or saline. During hypoxia AIx decreased by 12% following saline but increased by 14% after L-NMMA and Tr did not change. These findings suggest that hypoxia may induce NO-mediated vasodilatation of small muscular arteries but not the aorta.
低氧血症会增加静息时的肌肉交感神经活动，但不会增加去甲肾上腺素。
DOI：
10.1152/jappl.1989.66.4.1736
发表时间：
1989
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Rowell,LB;Johnson,DG;Chase,PB;Comess,KA;Seals,DR
通讯作者：
Seals,DR